adult-onset leukoencephalopathy with axonal spheroids and pigmented glia

info · Genetic

A leukodystrophy that is characterized by progressive dementia, apraxia, apathy, impaired balance, parkinsonism, spasticity and epilepsy and has_material_basis_in heterozygous mutation in the CSF1R gene on chromosome 5q32.

Signs and symptoms

Seizure
Global brain atrophy
Impaired executive functioning
Dysphagia
Parkinsonism
Memory impairment
Gait disturbance
Dysarthria
Corpus callosum atrophy
Mutism

Also known as: hereditary diffuse leukoencephalopathy with spheroids