adult-onset leukoencephalopathy without lacunae

A leukodystrophy characterized by a diffuse vascular leukoencephalopathy without lacunar infarct and a hippocampal type of memory defect with onset in the sixth to seventh decade that has_material_basis_in heterozygous mutation in the LAMB1 gene on chromosome

A leukodystrophy characterized by a diffuse vascular leukoencephalopathy without lacunar infarct and a hippocampal type of memory defect with onset in the sixth to seventh decade that has_material_basis_in heterozygous mutation in the LAMB1 gene on chromosome 7q31.

Signs and symptoms

• Hypoesthesia
• Vertigo
• Hypertensive retinopathy
• Migraine without aura
• Anterograde memory impairment
• Intention tremor
• Impaired executive functioning
• Depression
• Lack of insight
• Cerebral hemorrhage

Also known as: LUCAO