Alexander disease

info · Genetic · ICD-10: G31.86

A leukodystrophy that is characterized by the destruction of white matter and the formation of Rosenthal fibers consisting of abnormal clumps of protein that accumulate in astrocytes.

Signs and symptoms

Dysmetria
Ataxia
Babinski sign
Dysarthria
Palatal tremor
Abnormal dentate nucleus morphology
Fatigue
Microcoria
Pendular nystagmus
Drowsiness

Also known as: Alexander's disease