Conditions / Nervous system

amyotrophic lateral sclerosis-parkinsonism/dementia complex 1

info · Nervous system

A neurodegenerative disease characterized by chronic, progressive amyotrophic lateral sclerosis and parkinsonism-dementia. Susceptibility to this disease is influenced by heterozygous mutation in TRPM7 on 15q21.2.

Signs and symptoms

Abnormal lower motor neuron morphology
Bulbar palsy
Muscle spasm
Amyotrophic lateral sclerosis
Paralysis
Muscle weakness
Cerebral atrophy
Dementia
Parkinsonism

Medications that may treat it

edaravone riluzole taurursodiol tofersen

Also known as: ALS-PDC; Amyotrophic lateral sclerosis-parkinsonism-dementia of Guam syndrome; Guam disease; Lytico-Bodig disease; PDALS