aortic valve disease 2

A bicuspid aortic valve disease that has_material_basis_in heterozygous mutation in the SMAD6 gene on chromosome 15q22.

Signs and symptoms

• Calcification of the aorta
• Coarctation of aorta
• Bicuspid aortic valve
• Aortic aneurysm
• Aortic valve stenosis
• Aortic regurgitation
• Mitral regurgitation
• Ascending aortic dissection
• Patent foramen ovale
• Aortic tortuosity