aplasia of lacrimal and salivary glands

A syndrome characterized by irritable eyes, epiphora, xerostomia, variable aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands, and absence of the lacrimal puncta that has_material_basis_in heterozygous mutation in the FGF10 ge

A syndrome characterized by irritable eyes, epiphora, xerostomia, variable aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands, and absence of the lacrimal puncta that has_material_basis_in heterozygous mutation in the FGF10 gene on chromosome 5p12.

Signs and symptoms

• Carious teeth
• Xerostomia
• Absent lacrimal punctum
• Lacrimal gland hypoplasia
• Lacrimal gland aplasia

Also known as: ALSG; congenital absence of lacrimal puncta and salivary glands