Conditions / Genetic
autoimmune lymphoproliferative syndrome type 4
info · Genetic · ICD-10: D72.8
An autoimmune lymphoproliferative syndrome that has_material_basis_in somatic mutation in the NRAS gene or the KRAS gene on chromosome 12p12.
Signs and symptoms
- Autoimmunity
- Lymphoproliferative disorder
- Hepatomegaly
- Increased circulating immunoglobulin concentration
- Leukemia
- Increased total monocyte count
- Follicular hyperplasia
- Hemolytic anemia
- Increased total lymphocyte count
- Autoimmune thrombocytopenia
Also known as: ALPS type 4; ALPS type IV; ALPS4; RALD; RAS-associated autoimmune leukoproliferative disease