autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2

A CADASIL characterized by stroke, transient ischemic attacks, cognitive impairment, dementia, balance impairment, gait disturbance, headaches, and/or seizures associated with early confluent or confluent diffuse white matter hyperintensities that has_material

A CADASIL characterized by stroke, transient ischemic attacks, cognitive impairment, dementia, balance impairment, gait disturbance, headaches, and/or seizures associated with early confluent or confluent diffuse white matter hyperintensities that has_material_basis_in heterozygous mutation in the HTRA1 gene on chromosome 10q26.

Signs and symptoms

• Hyperintensity of cerebral white matter on MRI
• Lacunar stroke
• Status cribrosum
• Gait disturbance
• Stroke
• Transient ischemic attack
• Cognitive impairment
• Dilation of Virchow-Robin spaces
• Recurrent subcortical infarcts
• Mental deterioration

Also known as: CADASIL 2; autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy type 2