autosomal dominant nonsyndromic deafness 86

An autosomal dominant nonsyndromic deafness characterized by late-onset progressive hearing loss through p53-mediated hair cell apoptosis that has_material_basis_in heterozygous mutation in the THOC1 gene on chromosome 18p11.

Signs and symptoms

• Sensorineural hearing impairment
• Tinnitus
• Abnormal vestibular function
• Abnormal inner ear morphology

Also known as: DFNA86; autosomal dominant deafness 86