Conditions / Genetic

Bartter disease type 4b

info · Genetic · ICD-10: E26.8

A Bartter disease that has_material_basis_in simultaneous mutation in both the CLCNKA and CLCNKB genes.

Signs and symptoms

  • Hypochloremia
  • Renal insufficiency
  • Hypotonia
  • Generalized hypotonia
  • Motor delay
  • Hypernatriuria
  • Failure to thrive
  • Increased circulating aldosterone concentration
  • Hyperchloriduria
  • Intellectual disability

Also known as: BARTS4B; Bartter syndrome, type 4b, digenic; neonatal Bartter syndrome type 4B with sensorineural deafness