Caffey disease

A bone inflammation disease that causes bone changes, soft tissue swelling and irritability in infants. The disease has been associated with COL1A1 gene. It has symptom soft-tissue swelling, has symptom bone lesions, and has symptom irritability.

Signs and symptoms

• Subperiosteal bone formation
• Periosteal thickening of long tubular bones
• Tibial bowing
• Cortical irregularity
• Joint hypermobility
• Thickened cortex of the radius
• Calvarial hyperostosis
• Thickened cortex of the clavicle
• Thickened cortex of the ulna
• Thickened cortex of the mandible

Also known as: cortical congenital hyperostosis; infantile cortical hyperostosis