Chilblain lupus

info · Skin

A cutaneous form of systemic lupus erythermatosus that is characterized by painful nodular skin lesions precipitated by variation in temperatures, has_material_basis_in autosomal dominant inheritance of mutation in the TREX1 gene.

Signs and symptoms

Arthralgia
Antinuclear antibody positivity
Chilblains
Skin ulcer
Papillary dermal edema
Elevated erythrocyte sedimentation rate
Cutaneous photosensitivity
Autoamputation of digits
Abnormal nail morphology
Raynaud phenomenon