Conditions / Syndrome

CLOVES syndrome

info · Syndrome · ICD-10: Q87.3

A syndrome that is characterized by congenital lipomatous overgrowth, progressive, complex and mixed truncal vascular malformation, and epidermal nevi that has_material_basis_in somatic mosaicism for postzygotic activating mutations in the PIK3CA gene on chrom

A syndrome that is characterized by congenital lipomatous overgrowth, progressive, complex and mixed truncal vascular malformation, and epidermal nevi that has_material_basis_in somatic mosaicism for postzygotic activating mutations in the PIK3CA gene on chromosome 3q26.

Signs and symptoms

  • Capillary malformation
  • Venous malformation
  • Lipoma
  • Lower limb asymmetry
  • Hemihypertrophy
  • Macrodactyly
  • Scoliosis
  • Sandal gap
  • Overgrowth
  • Abnormal cardiovascular system morphology

Also known as: congenital lipomatous overgrowth, vascular malformations, and epidermal nevi