Coffin-Siris syndrome 8

A Coffin-Siris syndrome characterized by variable degrees of impaired intellectual development including speech impairment, hypotonia, feeding difficulties, and behavioral abnormalities and variable occurence of other dysmophic features that has_material_basis

A Coffin-Siris syndrome characterized by variable degrees of impaired intellectual development including speech impairment, hypotonia, feeding difficulties, and behavioral abnormalities and variable occurence of other dysmophic features that has_material_basis_in heterozygous mutation in the SMARCC2 gene on chromosome 12q13.

Signs and symptoms

• Intellectual disability
• Global developmental delay
• Hypotonia
• Delayed speech and language development
• Sleep disturbance
• Aggressive behavior
• Hyperactivity
• Self-injurious behavior
• Feeding difficulties
• Poor suck

Also known as: CSS8