common variable immunodeficiency 10

A common variable immunodeficiency that has_material_basis_in heterozygous mutation in the NFKB2 gene on chromosome 10q24.

Signs and symptoms

• Central adrenal insufficiency
• Abnormal response to ACTH stimulation test
• Decreased circulating IgG concentration
• Decreased circulating IgM concentration
• Asthma
• Combined immunodeficiency
• Recurrent viral upper respiratory tract infections
• Decreased circulating IgA concentration
• Recurrent pneumonia
• Recurrent oral herpes