common variable immunodeficiency 11

A common variable immunodeficiency that has_material_basis_in homozygous mutation in the IL21 gene on chromosome 4q27.

Signs and symptoms

• Inflammation of the large intestine
• Increased circulating IgE concentration
• Crohn's disease
• Decreased class-switched memory B cell proportion
• Fatigue
• Failure to thrive
• Clubbing of fingers
• Mucoid diarrhea
• Aphthous ulcer
• Recurrent respiratory infections