common variable immunodeficiency 3

A common variable immunodeficiency that has_material_basis_in homozygous or compound heterozygous mutation in the CD19 gene on chromosome 16p11.2.

Signs and symptoms

• Decreased class-switched memory B cell proportion
• Combined immunodeficiency
• Chronic decreased circulating total IgG concentration
• Decreased circulating isohemagglutinin concentration
• Recurrent otitis media
• Decreased circulating IgM concentration
• Decreased circulating IgA concentration
• Recurrent sinusitis
• Recurrent bacterial infections
• Recurrent respiratory infections