Conditions / Genetic
common variable immunodeficiency 6
info · Genetic
A common variable immunodeficiency that has_material_basis_in homozygous mutation in the CD81 gene on chromosome 11p.
Signs and symptoms
- Glomerulonephritis
- Stage 5 chronic kidney disease
- Complete or near-complete absence of specific antibody response to tetanus vaccine
- Hepatomegaly
- Chronic decreased circulating total IgG concentration
- Macroscopic hematuria
- Mesangial Immune complex deposition
- Decreased circulating specific pneumococcal antibody concentration
- Arthralgia
- Purpura