common variable immunodeficiency 7

A common variable immunodeficiency that has_material_basis_in compound heterozygous mutation in the CD21 gene (CR2) on chromosome 1q32.

Signs and symptoms

• Recurrent urinary tract infections
• Decreased circulating isohemagglutinin concentration
• Pharyngalgia
• Chronic absent circulating IgG4
• Decreased circulating specific pneumococcal antibody concentration
• Chronic decreased circulating IgG1 concentration
• Decreased circulating total IgG concentration
• Fever
• Splenomegaly
• Decreased circulating IgA concentration