complement component 3 deficiency

A complement deficiency that is characterized by deficiency of complement component 3 that increases susceptibility to infection and autoimmune diseases and has_material_basis_in autosomal recessive inheritance of mutation in the C3 gene on chromosome 19p13.3,

A complement deficiency that is characterized by deficiency of complement component 3 that increases susceptibility to infection and autoimmune diseases and has_material_basis_in autosomal recessive inheritance of mutation in the C3 gene on chromosome 19p13.3, with symptoms of recurrent bacterial infections.

Signs and symptoms

• Decreased circulating complement C3 concentration
• Recurrent tonsillitis
• Recurrent bacterial infections
• Recurrent fever
• Systemic lupus erythematosus
• Recurrent pneumonia
• Nephrotic syndrome
• Renal insufficiency
• Membranoproliferative glomerulonephritis

Also known as: C3 deficiency