complement component 5 deficiency

A complement deficiency that is characterized by susceptibility to recurrent bacterial infections especially to infections of enveloped organisms, and has_material_basis_in mutation in the complement component 5 (C5) gene on chromosome 9q33.2 that encodes the

A complement deficiency that is characterized by susceptibility to recurrent bacterial infections especially to infections of enveloped organisms, and has_material_basis_in mutation in the complement component 5 (C5) gene on chromosome 9q33.2 that encodes the fifth component of complenent, a part of the innate immune system.

Signs and symptoms

• Reduced circulating CH50 activity
• Recurrent Neisseria meningitidis infection
• Decreased circulating complement C5 concentration
• Intractable diarrhea
• Recurrent Neisserial infections
• Generalized seborrheic dermatitis

Also known as: C5 deficiency