complement factor I deficiency

A complement deficiency that is characterized by recurrent pyogenic bacterial infections that is the result of complement component 3 deficiency.

Signs and symptoms

• Decreased circulating complement factor I concentration
• Decreased circulating complement C3 concentration
• Recurrent Neisseria meningitidis infection
• Decreased circulating complement factor B concentration
• Glomerulonephritis
• Recurrent urinary tract infections
• Decreased circulating complement factor H concentration
• Recurrent streptococcus pneumoniae infections
• Renal insufficiency
• Recurrent Haemophilus influenzae infection

Also known as: C3 INACTIVATOR DEFICIENCY; COMPLEMENT COMPONENT 3 INACTIVATOR DEFICIENCY