corticosteroid-binding globulin deficiency

An adrenal gland disease characterized by decreased levels of serum corticosteroid-binding globulin and cortisol, and in some cases hypo- or hypertension, and muscle fatigue that has_material_basis_in heterozygous or homozygous mutation in the SERPINA6 gene on

An adrenal gland disease characterized by decreased levels of serum corticosteroid-binding globulin and cortisol, and in some cases hypo- or hypertension, and muscle fatigue that has_material_basis_in heterozygous or homozygous mutation in the SERPINA6 gene on chromosome 14q32.

Signs and symptoms

• Decreased circulating corticosteroid-binding globulin concentration
• Decreased urinary potassium
• Decreased circulating cortisol level
• Anemia
• Hypokalemia
• Hypotension
• Asthenia
• Increased muscle fatiguability
• Fatigue
• Hypertension

Also known as: CBG deficiency; transcortin deficiency