dilated cardiomyopathy 2D

A dilated cardiomyopathy that is characterized by neonatal onset of severe cardiomyopathy, with rapid progression to cardiac decompensation and death unless the patient undergoes heart transplantation and that has_material_basis_in homozygous or compound heter

A dilated cardiomyopathy that is characterized by neonatal onset of severe cardiomyopathy, with rapid progression to cardiac decompensation and death unless the patient undergoes heart transplantation and that has_material_basis_in homozygous or compound heterozygous mutation in the RPL3L gene on chromosome 16p13.

Signs and symptoms

• Interstitial cardiac fibrosis
• Reduced left ventricular ejection fraction
• Perinuclear cardiomyocyte vacuolization
• Dilated cardiomyopathy
• Pulmonary arterial hypertension
• Tricuspid regurgitation
• Mitral regurgitation
• Muscular ventricular septal defect
• Patent foramen ovale
• Cardiogenic shock