erythrokeratodermia variabilis et progressiva 3

An erythrokeratodermia variabilis that is characterized by normal skin at birth but develop hyperpigmentation and scaling at sites of friction in childhood, with progression to near-confluent corrugated hyperkeratosis, palmoplantar keratoderma, and transient f

An erythrokeratodermia variabilis that is characterized by normal skin at birth but develop hyperpigmentation and scaling at sites of friction in childhood, with progression to near-confluent corrugated hyperkeratosis, palmoplantar keratoderma, and transient figurate erythema and that has_material_basis_in heterozygous mutation in the gene encoding connexin-43 (GJA1) on chromosome 6q22.

Signs and symptoms

• Hypergranulosis
• Epidermal acanthosis
• Erythema
• Orthokeratosis
• Palmoplantar keratoderma
• Hyperkeratosis
• Leukonychia