factor VIII deficiency

A hemophilia that has_material_basis_in Factor VIII deficiency, which results in the formation of fibrin deficient clots which makes coagulation much more prolonged.

Signs and symptoms

• Bruising susceptibility
• Persistent bleeding after trauma
• Joint hemorrhage
• Reduced factor VIII activity
• Muscle hemorrhage
• Osteoarthritis
• Prolonged partial thromboplastin time
• Gingival bleeding
• Epistaxis
• Melena

Medications that may treat it

anti-inhibitor coagulant complex danaparoid dicumarol emicizumab factor IX factor VII factor VIII fitusiran marstacimab phenprocoumon valoctocogene roxaparvovec warfarin

Also known as: Congenital factor VIII disorder; Hemophilia A; Subhemophilia; classic hemophilia; classic hemophilia A