familial adenomatous polyposis 1

A familial adenomatous polyposis that is characterized by predisposition to cancer and that has_material_basis_in heterozygous mutation in the APC gene on chromosome 5q22. Affected individuals usually develop hundreds to thousands of adenomatous polyps of the

A familial adenomatous polyposis that is characterized by predisposition to cancer and that has_material_basis_in heterozygous mutation in the APC gene on chromosome 5q22. Affected individuals usually develop hundreds to thousands of adenomatous polyps of the colon and rectum, a small proportion of which will progress to colorectal carcinoma if not surgically treated.

Signs and symptoms

• Adenomatous colonic polyposis
• Congenital hypertrophy of retinal pigment epithelium
• Duodenal polyposis
• Multiple gastric polyps
• Multiple lipomas
• Carcinoma
• Odontoma
• Hyperpigmentation of the skin
• Astrocytoma
• Keloids

Also known as: adenocarcinoma in adenomatous polyposis coli