frontotemporal dementia 2

A frontotemporal dementia characterized by variable phenotypic expression typically including social, behavioral, or language deterioration, rather than memory or motor deficits and the presence of TARDBP-positive inclusions that has_material_basis_in mutation

A frontotemporal dementia characterized by variable phenotypic expression typically including social, behavioral, or language deterioration, rather than memory or motor deficits and the presence of TARDBP-positive inclusions that has_material_basis_in mutation in the GRN gene on chromosome 17q21.31.

Signs and symptoms

• Aphasia
• Mutism
• Decreased circulating progranulin concentration
• Frontotemporal dementia
• Cerebral cortical atrophy
• Apraxia
• Neurofibrillary tangles
• Hallucinations
• Progressive language deterioration
• Disinhibition

Also known as: GRN-related frontotemporal lobar degeneration with Tdp43 inclusions