Conditions / Other

Glanzmann's thrombasthenia

info · Other · ICD-10: D69.1

A blood coagulation disease characterized by autosomal recessive inheritance of failure of platelet aggregation and absent or diminished clot retraction that has_material_basis_in mutation in the ITGA2B or ITGB3 genes on chromosome 17q21.32.

Signs and symptoms

  • Excessive bleeding from superficial cuts
  • Ecchymosis
  • Impaired clot retraction
  • Impaired collagen-induced platelet aggregation
  • Subdural hemorrhage
  • Impaired epinephrine-induced platelet aggregation
  • Epistaxis
  • Impaired ADP-induced platelet aggregation
  • Decreased platelet glycoprotein IIb-IIIa
  • Menorrhagia

Medications that may treat it

factor VII

Also known as: BDPLT2; Glanzmann thrombasthenia; Glycoprotein IIb/IIIa defect; Thrombocytasthenia; deficiency of GP IIb-IIIa complex