glucocorticoid-remediable aldosteronism

A primary hyperaldosteronism characterized by variably expressed and severe hypertension, hyperaldosteronism and abnormal adrenal steroid production which improve with exogenous glucocorticoid administration that has_material_basis_in a chimeric gene formed of

A primary hyperaldosteronism characterized by variably expressed and severe hypertension, hyperaldosteronism and abnormal adrenal steroid production which improve with exogenous glucocorticoid administration that has_material_basis_in a chimeric gene formed of the CYP11B2 and CYP11B1 genes on chromosome 8q24.3.

Signs and symptoms

• Abnormality of the urinary system
• Increased circulating aldosterone concentration
• Decreased circulating renin concentration
• Adrenal hyperplasia
• Hypertension
• Adrenogenital syndrome

Also known as: GRA; GRS; familial hyperaldosteronism type I; glucocorticoid-suppressible hyperaldosteronism