Conditions / Nervous system
hereditary sensory and autonomic neuropathy type 5
info · Nervous system
A hereditary sensory and autonomic neuropathy characterized by impaired pain and thermal perception in the extremities and selective reduction in small myelinated fibers that has_material_basis_in homozygous mutation in the NGF gene on chromosome 1p13.
Signs and symptoms
- Painless fractures due to injury
- Pain insensitivity
- Peripheral neuropathy
- Impaired pain sensation
- Acral ulceration
- Osteomyelitis
- Diarrhea
- Hand tremor
- Impaired vibratory sensation
- Impaired temperature sensation
Also known as: HSAN5; hereditary sensory and autonomic neuropathy type V