Conditions / Nervous system
hereditary sensory neuropathy type 1E
info · Nervous system
A hereditary sensory and autonomic neuropathy type 1 characterized by adult onset of progressive peripheral sensory loss, progressive hearing impairment, and early-onset dementia that has_material_basis_in heterozygous mutation in the DNMT1 gene on chromosome
A hereditary sensory and autonomic neuropathy type 1 characterized by adult onset of progressive peripheral sensory loss, progressive hearing impairment, and early-onset dementia that has_material_basis_in heterozygous mutation in the DNMT1 gene on chromosome 19p13.
Signs and symptoms
- Dementia
- Sensory neuropathy
- Hearing impairment
- Hyporeflexia
- Cerebral atrophy
- Memory impairment
- Excessive daytime somnolence
- Decreased number of peripheral myelinated nerve fibers
- Delirium
- Impulsivity
Also known as: HSAN1E; HSN1E; hereditary sensory and autonomic neuropathy type 1E; hereditary sensory and autonomic neuropathy type IE; hereditary sensory neuropathy type IE