hereditary spastic paraplegia 10

A hereditary spastic paraplegia that has_material_basis_in mutation in the KIF5A gene on chromosome 12q13.

Signs and symptoms

• Babinski sign
• Spastic gait
• Lower limb muscle weakness
• Lower limb hypertonia
• Impaired vibration sensation in the lower limbs
• Pes cavus
• Distal sensory impairment
• Scoliosis
• Urinary urgency
• Upper limb muscle weakness

Also known as: SPG10; autosomal dominant spastic paraplegia 10; autosomal dominant spastic paraplegia type 10