Conditions / Genetic
hereditary spastic paraplegia 12
info · Genetic · ICD-10: G11.4
A hereditary spastic paraplegia that has_material_basis_in mutation in the RTN2 gene on chromosome 19q13.
Signs and symptoms
- Leg muscle stiffness
- Scissor gait
- Lower limb muscle weakness
- Chronic constipation
- Lower limb hypertonia
- Brisk reflexes
- Myalgia
- Lower limb hyperreflexia
- Pneumonia
- Ankle clonus
Also known as: SPG12; autosomal dominant spastic paraplegia 12; autosomal dominant spastic paraplegia type 12