hereditary spastic paraplegia 13

A hereditary spastic paraplegia that is characterized by a pure form of the disease with late onset and has_material_basis_in mutation in the HSPD1 gene on chromosome 2q33.

Signs and symptoms

• Impaired vibration sensation in the lower limbs
• Urinary urgency
• Babinski sign
• Lower limb muscle weakness
• Urinary incontinence
• Spastic gait
• Urinary bladder sphincter dysfunction
• Lower limb spasticity
• Spastic paraplegia
• Hyperreflexia

Also known as: SPG13; autosomal dominant spastic paraplegia 13