Conditions / Genetic
hereditary spastic paraplegia 15
info · Genetic · ICD-10: G11.4
A hereditary spastic paraplegia that has_material_basis_in mutation in the ZFYVE26 gene on chromosome 14q24.1.
Signs and symptoms
- Peripheral axonal neuropathy
- Clonus
- Distal amyotrophy
- Urinary incontinence
- Spastic gait
- Ataxia
- Lower limb spasticity
- Paraplegia
- Lower limb muscle weakness
- Urinary bladder sphincter dysfunction
Also known as: Kjellin syndrome; SPG15; autosomal recessive spastic paraplegia 15; autosomal recessive spastic paraplegia type 15; hereditary spastic paraparesis type 15