hereditary spastic paraplegia 17

A hereditary spastic paraplegia that has_material_basis_in mutation in the BSCL2 gene on chromosome 11q12.

Signs and symptoms

• Decreased motor nerve conduction velocity
• Impaired distal proprioception
• Babinski sign
• Pes cavus
• Distal amyotrophy
• Impaired distal tactile sensation
• Distal muscle weakness
• Postural tremor
• Split hand
• Spastic paraplegia

Also known as: SPG17; Silver spastic paraplegia syndrome; Silver syndrome; autosomal dominant spastic paraplegia 17; autosomal dominant spastic paraplegia type 17