hereditary spastic paraplegia 19

A hereditary spastic paraplegia that has_material_basis_in variation in the chromosome region 9q.

Signs and symptoms

• Impaired vibration sensation in the lower limbs
• Urinary urgency
• Babinski sign
• Urinary incontinence
• Spastic gait
• Lower limb spasticity
• Knee clonus
• Ankle clonus
• Lower limb muscle weakness
• Urinary bladder sphincter dysfunction

Also known as: SPG19; autosomal dominant spastic paraplegia 19; autosomal dominant spastic paraplegia type 19