Conditions / Genetic
hereditary spastic paraplegia 2
info · Genetic · ICD-10: G11.4
A hereditary spastic paraplegia that has_material_basis_in mutation in the PLP1 gene on chromosome Xq22.2.
Signs and symptoms
- Nystagmus
- Skeletal muscle atrophy
- Babinski sign
- Dysmetria
- Pes cavus
- Flexion contracture
- Dysarthria
- Spastic gait
- Lower limb spasticity
- Lower limb muscle weakness
Also known as: SPG2; X-linked spastic paraplegia 2; spastic paraplegia type 2