hereditary spastic paraplegia 23

A hereditary spastic paraplegia that has_material_basis_in variation in the chromosome region 1q24-q32.

Signs and symptoms

• Vitiligo
• Multiple lentigines
• Mild intellectual disability
• Babinski sign
• Hyperpigmentation in sun-exposed areas
• Premature graying of body hair
• Lower limb muscle weakness
• Spastic paraplegia
• Hyperreflexia
• Loss of ambulation

Also known as: Lison syndrome; SPG23; Spastic paraparesis-vitiligo-premature graying-characteristic facies syndrome; spastic paraplegia 23; spastic paraplegia with pigmentary abnormalities