Conditions / Genetic
hereditary spastic paraplegia 28
info · Genetic · ICD-10: G11.4
A hereditary spastic paraplegia that has_material_basis_in mutation in the DDHD1 gene on chromosome 14q22.
Signs and symptoms
- Hyperreflexia
- Scoliosis
- Pes cavus
- Gait disturbance
- Babinski sign
- Lower limb spasticity
- Lower limb muscle weakness
- Distal sensory impairment
- Peripheral axonal neuropathy
- Spastic paraplegia
Also known as: SPG28; autosomal recessive spastic paraplegia 28; autosomal recessive spastic paraplegia type 28