hereditary spastic paraplegia 36

A hereditary spastic paraplegia that has_material_basis_in variation in the chromosome region 12q23-q24.

Signs and symptoms

• Impaired vibration sensation in the lower limbs
• Urinary urgency
• Pes cavus
• Babinski sign
• Urinary incontinence
• Spastic gait
• Lower limb spasticity
• Demyelinating sensory neuropathy
• Lower limb muscle weakness
• Demyelinating motor neuropathy

Also known as: SPG36; autosomal dominant spastic paraplegia 36; autosomal dominant spastic paraplegia type 36