hereditary spastic paraplegia 38

A hereditary spastic paraplegia that has_material_basis_in variation in the chromosome region 4p16-p15.

Signs and symptoms

• Impaired vibration sensation in the lower limbs
• Pes cavus
• Babinski sign
• Distal amyotrophy
• Spastic gait
• Distal muscle weakness
• Lower limb spasticity
• First dorsal interossei muscle weakness
• Thenar muscle atrophy
• Lower limb muscle weakness

Also known as: SPG38; autosomal dominant spastic paraplegia 38; autosomal dominant spastic paraplegia type 38