hereditary spastic paraplegia 3A

A hereditary spastic paraplegia that is characterized by lower limb weakness and spasticity that is generally non-progressive or extremely slow and has_material_basis_in mutation in the ATL1 gene on chromosome 14q22.

Signs and symptoms

• Lower limb muscle weakness
• Scoliosis
• Impaired vibration sensation in the lower limbs
• Urinary urgency
• Pes cavus
• Babinski sign
• Urinary incontinence
• Spastic gait
• Lower limb spasticity
• Motor delay

Also known as: FSP1; SPG3A; autosomal dominant familial spastic paraplegia 1; autosomal dominant spastic paraplegia 3; autosomal dominant spastic paraplegia type 3