hereditary spastic paraplegia 4

A hereditary spastic paraplegia that is characterized by slowly progressive muscle weakness and spasticity and has_material_basis_in mutation in the SPAST gene on chromosome 2p22.

Signs and symptoms

• Impaired vibration sensation in the lower limbs
• Urinary incontinence
• Spastic gait
• Lower limb spasticity
• Nystagmus
• Depression
• Paraplegia
• Lower limb muscle weakness
• Aggressive behavior
• Urinary bladder sphincter dysfunction

Also known as: SPG4; autosomal dominant spastic paraplegia 4; autosomal dominant spastic paraplegia type 4