hereditary spastic paraplegia 6

A hereditary spastic paraplegia that is usually characterized by rapidly progressive and severe spastic paraplegia and has_material_basis_in mutation in the NIPA1 gene on chromosome 15q11.2.

Signs and symptoms

• Clonus
• Impaired vibration sensation in the lower limbs
• Urinary urgency
• Pes cavus
• Babinski sign
• Seizure
• Urinary incontinence
• Spastic gait
• Lower limb spasticity
• Lower limb muscle weakness

Also known as: FSP3; SPG6; autosomal dominant familial spastic paraplegia type 3; autosomal dominant spastic paraplegia 6; autosomal dominant spastic paraplegia type 6