hereditary spastic paraplegia 7

A hereditary spastic paraplegia that is characterized by slowly progressive onset, usually between 18-60 years of age, and generally more severe spasticity and has_material_basis_in mutation in the SPG7 gene on chromosome 16q24.

Signs and symptoms

• Lower limb spasticity
• Impaired executive functioning
• Gait disturbance
• Lower limb hyperreflexia
• Dysarthria
• Supranuclear gaze palsy
• Postural instability
• Cerebellar atrophy
• Lower limb hypertonia
• Spastic ataxia

Also known as: SPG7; autosomal recessive spastic paraplegia 7; spastic paraplegia type 7