hereditary spastic paraplegia 8

A hereditary spastic paraplegia that has_material_basis_in mutation in the KIAA0196 gene on chromosome 8q24.

Signs and symptoms

• Impaired vibration sensation in the lower limbs
• Babinski sign
• Lower limb hyperreflexia
• Lower limb spasticity
• Spastic paraplegia
• Urinary urgency
• Upper limb hyperreflexia
• Lower limb muscle weakness
• Urinary incontinence
• Spastic gait

Also known as: SPG8; autosomal dominant spastic paraplegia 8; autosomal dominant spastic paraplegia type 8