hypogonadotropic hypogonadism 16 with or without anosmia

A hypogonadotropic hypogonadism that has_material_basis_in mutation in the SEMA3A gene on chromosome 7, sometimes in association with mutations in other genes.

Signs and symptoms

• Decreased circulating luteinizing hormone level
• Decreased circulating follicle stimulating hormone concentration
• Decreased serum testosterone concentration
• Decreased serum estradiol
• Primary amenorrhea
• Hyposmia
• Hypogonadism
• Hypoplasia of the olfactory bulb
• Micropenis
• Decreased testicular size