Conditions / Genetic

hypogonadotropic hypogonadism 3 with or without anosmia

info · Genetic · ICD-10: E23.0

A hypogonadotropic hypogonadism that has_material_basis_in heterozygous mutation in the PROKR2 gene on chromosome 20p12, sometimes in association with mutation in another gene.

Signs and symptoms

  • Aplasia of the olfactory bulb
  • Hypogonadotropic hypogonadism
  • Cleft palate
  • Micropenis
  • Unilateral renal agenesis
  • Hypotelorism
  • Hyposmia
  • Cleft upper lip
  • Primary amenorrhea
  • Pes planus